The 5′ and 3′ ends of eukaryotic mRNAs are brought together to form a closed loop, which helps stabilize the mRNA and facilitates translation. There are two distinct closed loops formed in yeast, which differ in the form of the ribosome that is bound. The form containing the full ribosome is also surprisingly associated with termination factors, even though termination is not required for loop formation.
- Nadia Amrani
- Shubhendu Ghosh
- Allan Jacobson
