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Showing 1–2 of 2 results
Advanced filters: Author: Shucheng Gan Clear advanced filters

  • Stat6 promotes M2 macrophage polarization. Here the authors characterize Trim24-CBP-Stat6 circuit regulating M2 macrophage polarization via Stat6 acetylation, and show it contributes to pro-tumorigenic macrophage activity in mice.

    • Tao Yu
    • Shucheng Gan
    • Yichuan Xiao
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Systemic lupus erythematosus (SLE) is an autoimmune disorder mediated by excessive autoantibodies. Here the authors show that an E3 ubiquitin ligase, Peli1, negatively modulates noncanonical NF-κB signaling to restrain lupus-like symptoms in mice, and that Peli1 expression inversely correlates with SLE severity in humans.

    • Junli Liu
    • Xinfang Huang
    • Yichuan Xiao
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13