Using a genome-wide association studies approach and patient brain tissue, Kim, Hwang et al. link Ebp1 to Alzheimer’s disease (AD). They show that a conditional Ebp1 knockout mouse model mimics phenotypes of sporadic AD and find that EBP1 reduces amyloid β production by inhibiting γ-secretase.
- Byeong-Seong Kim
- Inwoo Hwang
- Jee-Yin Ahn
