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Showing 1–5 of 5 results

Advanced filters: Author: Shuzo Sugita Clear advanced filters

Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans

Opening of the UNC-64/syntaxin closed conformation by UNC-13/Munc13 to form the neuronal SNARE complex is critical for neurotransmitter release. Here the authors show that facilitating the opening of syntaxin enhances exocytosis not only in unc-13 nulls as well as in diverse C. elegans mutants.

Chi-Wei Tien
Bin Yu
Shuzo Sugita
ResearchOpen Access02 Nov 2020
Nature Communications

Volume: 11, P: 1-18
SNAP-25, but not SNAP-23, is essential for photoreceptor development, survival, and function in mice

A study using photoreceptor-specific knockout mice finds that SNAP-25, and not SNAP-23, is the isoform crucial for photoreceptor development, survival, and function. Mechanistically, SNAP-25 mediates photopigment trafficking and synaptic functioning.

Mengjia Huang
Chun Hin Chow
Shuzo Sugita
ResearchOpen Access05 Jan 2024
Communications Biology

Volume: 7, P: 1-14
A conformational switch in the Piccolo C₂A domain regulated by alternative splicing

Jesus Garcia
Stefan H Gerber
Josep Rizo
Research29 Dec 2003
Nature Structural & Molecular Biology

Volume: 11, P: 45-53
Extracellular phosphorylation drives the formation of neuronal circuitry

Via its receptor LRP5, Wnt3a stimulates axonal growth in retinal ganglion neurons. Phosphorylation of co-receptor RGMb by VLK induces LRP5 internalization to limit Wnt3a signaling and reduce axon growth.

Hidekiyo Harada
Nahal Farhani
Philippe P. Monnier
Research26 Aug 2019
Nature Chemical Biology

Volume: 15, P: 1035-1042
Syntaxin-3 is dispensable for basal neurotransmission and synaptic plasticity in postsynaptic hippocampal CA1 neurons

Shan Shi
Ke Ma
Shuzo Sugita
ResearchOpen Access20 Jan 2020
Scientific Reports

Volume: 10, P: 1-11