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Showing 1–5 of 5 results
Advanced filters: Author: Sibei Xu Clear advanced filters

  • Adaptive laboratory evolution experiments in Escherichia coli show that the pseudogene efeU can be repaired to restore the bacterium’s iron uptake system, demonstrating that pseudogenes may serve as an ‘adaptive repertoire’ of selectable traits.

    • Amitesh Anand
    • Connor A. Olson
    • Bernhard O. Palsson
    Research
    Nature Microbiology
    Volume: 4, P: 386-389

  • Mechanistic insight into the regulation of transcriptional modules remains scarce. Here, the authors identify statistically independent gene sets by applying independent component analysis to a high-quality E. coli RNA-seq data compendium and find that most gene sets represent the effects of specific transcriptional regulators.

    • Anand V. Sastry
    • Ye Gao
    • Bernhard O. Palsson
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • The function of metabolic genes in the context of regulatory networks is not well understood. Here, the authors investigate the adaptive responses of E. coli after knockout of metabolic genes and highlight the influence of metabolite levels in the evolution of regulatory function.

    • Douglas McCloskey
    • Sibei Xu
    • Bernhard O. Palsson
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15