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Showing 1–3 of 3 results
Advanced filters: Author: Sibes Bera Clear advanced filters

  • Pandey, Bera, Shi et al. report the cryo-electron microscopy structure of the Rous sarcoma virus octameric intasome complex stabilized by a HIV-1 integrase strand transfer inhibitor. This new structure highlights the intrinsic flexibility of the distal integrase subunits and suggests that ordered conformational transitions occur within the conserved intasome core during the assembly process.

    • Krishan K. Pandey
    • Sibes Bera
    • Duane P. Grandgenett
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-10

  • Integration of the reverse-transcribed viral DNA into host chromosomes is a critical step in the life-cycle of retroviruses such as the human T-cell leukemia virus type-1 (HTLV-1). Here the authors describe the structural role of the host co-factor protein phosphatase 2A B56γ subunit in supporting integration as part of the HTLV-1 intasome.

    • Veer Bhatt
    • Ke Shi
    • Hideki Aihara
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9