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Site-specific activation of the proton pump inhibitor rabeprazole by tetrathiolate zinc centres

Proton pump inhibitors (PPIs) are prodrugs that are activated by protonation in the highly acidic environment of the stomach lining. Now, coordination of PPIs to protein-bound zinc ions is revealed as another pathway to PPI activation. Acting as a Lewis acid, the zinc ion facilitates conjugation of the drug to zinc-coordinating cysteine residues.

Teresa Marker
Raphael R. Steimbach
Tobias P. Dick
ResearchOpen Access20 Feb 2025
Nature Chemistry

Volume: 17, P: 507-517
The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility

Use of live cell imaging of vaccinia virus-infected cells with fluorescence bleaching shows that the turnover rate of N-WASP (an activator of the ARP2/3 complex) is inversely proportional to the rate of actin-based motility of the virus. Actin polymerization is also required to promote N-WASP turnover on the virus. These observations are consistent with a model in which the stability of N-WASP association beneath the virus controls the overall rate of Arp2/3 complex-dependent actin-based motility.

Ina Weisswange
Timothy P. Newsome
Michael Way
Research05 Mar 2009
Nature

Volume: 458, P: 87-91
Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell division

The cell cycle regulates translation during mitosis by controlling DENR stability. Here, the authors show the non-canonical translation initiation complex DENR·MCTS1 is phosphorylated during mitosis by CDK1 and 2, enabling the translation of genes needed for proper mitotic progression.

Katharina Clemm von Hohenberg
Sandra Müller
Aurelio A. Teleman
ResearchOpen Access03 Feb 2022
Nature Communications

Volume: 13, P: 1-14
DENR–MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth

This study identifies the DENR–MCT-1 complex as the first factors in animals specific for translation re-initiation downstream of upstream Open Reading Frames (uORFs).

Sibylle Schleich
Katrin Strassburger
Aurelio A. Teleman
Research06 Jul 2014
Nature

Volume: 512, P: 208-212
Identification of transcripts with short stuORFs as targets for DENR•MCTS1-dependent translation in human cells

Sibylle Schleich
Julieta M. Acevedo
Aurelio A. Teleman
ResearchOpen Access16 Jun 2017
Scientific Reports

Volume: 7, P: 1-11

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Site-specific activation of the proton pump inhibitor rabeprazole by tetrathiolate zinc centres

The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility

Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell division

DENR–MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth

Identification of transcripts with short stuORFs as targets for DENR•MCTS1-dependent translation in human cells

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