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Showing 1–5 of 5 results
Advanced filters: Author: Siddartha Tamang Clear advanced filters
  • Self-assembly of small drugs with organic dyes represents a facile route to synthesize nanoparticles with high drug-loading capability. Here the authors combine a machine learning approach with high-throughput experimental validation to identify which combinations of drugs and excipient lead to successful nanoparticle formation and characterize the therapeutic efficacy of two of them in vitro and in animal models.

    • Daniel Reker
    • Yulia Rybakova
    • Giovanni Traverso
    Research
    Nature Nanotechnology
    Volume: 16, P: 725-733
  • High swelling ratio, speed and long term robustness tend not coexist in hydrogels which limits their use in devices. Here, the authors introduce a pufferfish-inspired hydrogel device ingested as a standard-sized pill, swells rapidly and maintains robustness under repeated mechanical loads in the stomach.

    • Xinyue Liu
    • Christoph Steiger
    • Xuanhe Zhao
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10
  • A luminal unfolding microneedle injector device (LUMI) is engineered as a custom capsule capable of efficient biologic macromolecular drug delivery into the bloodstream via selective deployment within the gastrointestinal tract.

    • Alex Abramson
    • Ester Caffarel-Salvador
    • Giovanni Traverso
    Research
    Nature Medicine
    Volume: 25, P: 1512-1518