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Showing 1–4 of 4 results
Advanced filters: Author: Siddhartha Devarakonda Clear advanced filters

  • Small cell lung cancer (SCLC) patients frequently relapse and become resistant to chemotherapy. Here, the authors analyse the genomic and transcriptomic landscape of primary and relapsed SCLC patients as well as in vitro models, and discover that activation of WNT signalling can drive chemotherapy resistance.

    • Alex H. Wagner
    • Siddhartha Devarakonda
    • Ramaswamy Govindan
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • The genomic and host factors that drive the progression of pre-invasive lesions in non-small cell lung cancer are poorly understood. Studying these factors can advance our knowledge of lung cancer biology, aid in the development of better screening strategies and improve patient outcomes.

    • Siddhartha Devarakonda
    • Ramaswamy Govindan
    Comments & OpinionOpen Access
    Nature Communications
    Volume: 10, P: 1-3

  • Analysing the regulatory consequences of mutations and splice variants at large scale in cancer requires efficient computational tools. Here, the authors develop RegTools, a software package that can identify splice-associated variants from large-scale genomics and transcriptomics data with efficiency and flexibility.

    • Kelsy C. Cotto
    • Yang-Yang Feng
    • Malachi Griffith
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18