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Showing 1–4 of 4 results
Advanced filters: Author: Sidinh Luc Clear advanced filters

  • The identity and lineage potential of the embryonic thymus-seeding progenitors that first seed the embryonic thymic rudiment is unclear. Jacobsen and colleagues find that these cells do not include multipotent stem cells or T cell–restricted progenitors but instead are lympho-myeloid progenitors.

    • Tiago C Luis
    • Sidinh Luc
    • Sten Eirik W Jacobsen
    Research
    Nature Immunology
    Volume: 17, P: 1424-1435

  • The commitment stage at which progenitors seed the thymus remains unclear. Jacobsen and colleagues show that the earliest progenitors in the neonatal thymus have combined myeloid, T lymphocyte and B lymphocyte potential but not megakaryocyte-erythroid potential.

    • Sidinh Luc
    • Tiago C Luis
    • Sten Eirik W Jacobsen
    Research
    Nature Immunology
    Volume: 13, P: 412-419

  • A CRISPR-Cas9 approach is used to perform saturating mutagenesis of the human and mouse BCL11A enhancers, producing a map that reveals critical regions and specific vulnerabilities; BCL11A enhancer disruption is validated by CRISPR-Cas9 as a therapeutic strategy for inducing fetal haemoglobin by applying it in both mice and primary human erythroblast cells.

    • Matthew C. Canver
    • Elenoe C. Smith
    • Daniel E. Bauer
    Research
    Nature
    Volume: 527, P: 192-197