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Showing 1–10 of 10 results
Advanced filters: Author: Sidonia B. G. Eckle Clear advanced filters

  • Mucosal-associated invariant T cells recognize vitamin-B-derived ligands presented via the major-histocompatibility-complex-like molecule MR1. Rossjohn and colleagues demonstrate that these cells recognize a wide variety of ligands, some derived from common drugs, in an agonist or antagonist manner.

    • Andrew N Keller
    • Sidonia B G Eckle
    • Jamie Rossjohn
    Research
    Nature Immunology
    Volume: 18, P: 402-411

  • Mucosal-Associated Invariant T (MAIT) cells are associated with established functions during bacterial infection. Here the authors show inoculation with Francisella tularensis results in induction of MAIT cells associated with prototypic Th1 immunity and confer protection to systemic and local infection.

    • Zhe Zhao
    • Huimeng Wang
    • Zhenjun Chen
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • T-cell receptors expressed on mucosal-associated invariant T cells function in a similar manner to innate immune receptors by recognizing small molecules such as microbial metabolites. Here, the authors report structures of this receptor in complex with vitamin B metabolites presented by the MHC-like protein MR1.

    • Onisha Patel
    • Lars Kjer-Nielsen
    • Jamie Rossjohn
    Research
    Nature Communications
    Volume: 4, P: 1-9

  • MAIT cells are abundant in the lungs and confer protection against bacterial pathogens. Whilst activation of these cells has been described during viral infections, here van Wilgenburg and colleagues show that in a murine model MAIT cells contribute to the protective host immune response to influenza virus infection.

    • Bonnie van Wilgenburg
    • Liyen Loh
    • Timothy S. C. Hinks
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9

  • Activation of mucosal-associated invariant T (MAIT) cells is shown to require key genes encoding an early intermediate in bacterial riboflavin synthesis, 5-amino-6-d-ribitylaminouracil; this reacts non-enzymatically with metabolites to form short-lived antigens that are captured and stabilized by MR1 for presentation to MAIT cells.

    • Alexandra J. Corbett
    • Sidonia B. G. Eckle
    • James McCluskey
    Research
    Nature
    Volume: 509, P: 361-365

  • MR1 molecules present bacterial metabolites to MAIT innate lymphocytes, but the processing and presentation pathway of these ligands are unclear. McCluskey, Rossjohn, Villadangos and colleagues demonstrate that MR1 ligands bind in the ER, which initiates trafficking to the plasma membrane and subsequent presentation.

    • Hamish E G McWilliam
    • Sidonia B G Eckle
    • Jose A Villadangos
    Research
    Nature Immunology
    Volume: 17, P: 531-537

  • Mucosal-associated invariant T (MAIT) cells recognize vitamin B metabolites presented by the molecule MR1. Rossjohn and colleagues generate multiple altered metabolite ligands and determine their structures in the context of MR1 and the TCR to develop a generalized framework for MAIT cell antigen recognition.

    • Wael Awad
    • Geraldine J. M. Ler
    • Jamie Rossjohn
    Research
    Nature Immunology
    Volume: 21, P: 400-411

  • Mucosal associated invariant T (MAIT) cells have been implicated in antibacterial responses. Here the authors show MAIT cells confer IFN-γ-mediated protection from lethal infection in a mouse model of Legionella infection, which can be enhanced by synthetic MR1 ligands.

    • Huimeng Wang
    • Criselle D’Souza
    • Zhenjun Chen
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15