The antidepressant vortioxetine affects rodent and human 5-HT3 receptors differently. López-Sánchez et al. use a variety of methods, including structure determination of vortioxetine-bound human and mouse 5-HT3 receptors, to reveal the basis of these differences.
- Uriel López-Sánchez
- Lachlan Jake Munro
- Anders S. Kristensen
