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Showing 1–3 of 3 results
Advanced filters: Author: Sigrid Fey Clear advanced filters

  • The function of wild-type KRAS in KRAS mutant cancers remains to be explored. Here, the authors show that deletion of the tumour-suppressive wild-type Kras in a KRASG12D driven colon cancer model exacerbates tumour initiation in a MAPK dependent manner, while acting to suppress metastasis through impaired immune suppression.

    • Arafath K. Najumudeen
    • Sigrid K. Fey
    • Owen J. Sansom
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Right-sided colorectal cancer (rCRC) has a different mutational spectrum to the left-sided counterpart. Here the authors develop a mouse model of rCRC that recapitulates human BRAF-mutant rCRC and show that loss of TGFβ-receptor signalling and inflammation induce the development of colonic tumours with a foetal-like phenotype.

    • Joshua D. G. Leach
    • Nikola Vlahov
    • Owen J. Sansom
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15