Daniel Gudbjartsson, Kari Stefansson and colleagues propose a new weighted Bonferroni approach for determining significance thresholds for human genome-wide association studies (GWAS). They demonstrate that the weighted approach, which is based on sequence annotation enrichments, improves power over standard GWAS methods.
- Gardar Sveinbjornsson
- Anders Albrechtsen
- Kari Stefansson
