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Cell Death and Differentiation (2)
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Showing 1–5 of 5 results

Advanced filters: Author: Silvia Alvarez-Diaz Clear advanced filters

Is SIRT2 required for necroptosis?

Kim Newton
Joanne M. Hildebrand
John Silke
Research26 Feb 2014
Nature

Volume: 506, P: E4-E6
Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

LUBAC is a ubiquitin ligase complex of HOIL-1, HOIP and SHARPIN important for signal transduction of a range of stimuli. Here the authors define the function of all three LUBAC components in T cell development and homeostasis.

Charis E. Teh
Najoua Lalaoui
Daniel H. D. Gray
ResearchOpen Access18 Nov 2016
Nature Communications

Volume: 7, P: 1-15
LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

The HOIL-1 component of the LUBAC ubiquitin ligase complex is required for LUBAC activity, which prevents lethality during embryogenesis by preventing aberrant TNFR1-mediated endothelial cell death and RIPK1-mediated defects in haematopoiesis.

Nieves Peltzer
Maurice Darding
Henning Walczak
Research25 Apr 2018
Nature

Volume: 557, P: 112-117
Loss of RIPK3 does not impact MYC-driven lymphomagenesis or chemotherapeutic drug-induced killing of malignant lymphoma cells

Rachel Thijssen
Silvia Alvarez-Diaz
David C. S. Huang
Comments & OpinionOpen Access18 Jun 2020
Cell Death & Differentiation

Volume: 27, P: 2531-2533
Necroptosis is dispensable for the development of inflammation-associated or sporadic colon cancer in mice

Silvia Alvarez-Diaz
Adele Preaudet
James M. Murphy
Research23 Nov 2020
Cell Death & Differentiation

Volume: 28, P: 1466-1476