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Showing 1–4 of 4 results
Advanced filters: Author: Silvia Angiolillo Clear advanced filters

  • Chronic desynchronization between physiological and behavioral rhythms has been linked to the onset of metabolic diseases. Here the authors control the cyclic metabolic signals in a microfluidic device to study the effects of the timing, period and frequency of glucose and insulin on the transcriptome of cultured fibroblasts.

    • Onelia Gagliano
    • Camilla Luni
    • Nicola Elvassore
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • The contribution of cell-extrinsic factors during cellular reprogramming to human induced pluripotent stem cells has long been overlooked. Here, the authors show functional protein communication between reprogramming intermediates and the re-shaping of a permissive extracellular environment.

    • Francesco Panariello
    • Onelia Gagliano
    • Nicola Elvassore
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Huntington’s disease is caused by mutation in the HTT gene. Here, the authors screen for suppressors of mutant HTT-induced toxicity, identifying Mtf1. Mtf1 reduced oxidative stress and cell death in stem cells, and motor defects and protein aggregates in mouse models.

    • Giorgia Maria Ferlazzo
    • Anna Maria Gambetta
    • Graziano Martello
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-24

  • We developed tissue-engineered neuromuscular organoids by combining decellularized skeletal muscle and hiPSCs. The provided ECM scaffolds improved cell maturation, enabling the study of (dys)functional skeletal muscle.

    • Beatrice Auletta
    • Pietro Chiolerio
    • Anna Urciuolo
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-17