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Showing 1–3 of 3 results
Advanced filters: Author: Silvia C. Finnemann Clear advanced filters

  • Here the authors provide evidence that 3D chromatin structure in the mouse brain differs between males and females and undergoes dynamic remodelling during the female ovarian cycle. They show female-specific 3D genome dynamics affects neuronal gene expression and brain disorder-relevant genes, and could play a role in reproductive hormone-induced brain plasticity and female-specific risk for brain disorders.

    • Devin Rocks
    • Mamta Shukla
    • Marija Kundakovic
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Retinitis pigmentosa is often caused by mutations that affect the activity or transport of rhodopsin, but some mutations cause disease even though an apparently functional protein is produced. Here the authors show that three such enigmatic mutants retain scramblase activity but are unable to dimerize.

    • Birgit Ploier
    • Lydia N. Caro
    • Anant K. Menon
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11