Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–3 of 3 results
Advanced filters: Author: Silvia Jimeno-González Clear advanced filters
  • The ATM kinase is a key regulator of the DNA damage response to double-strand breaks (DSBs) and its homozygous loss in patients predisposes to lymphoid malignancies. Here, the authors develop a Tdp2−/− Atm−/− double-deficient mouse model to uncover topoisomerase II-induced DSBs as significant drivers of the genomic rearrangements that underpin these tumours.

    • Alejandro Álvarez-Quilón
    • José Terrón-Bautista
    • Felipe Cortés-Ledesma
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14
  • Different roles of specific RNA-related factors in DNA repair have now been reported. Here the authors reveal a role for RNA-editing by ADAR in DNA end resection following double strand break formation and a change in pattern of ADAR2-mediated A-to-I editing.

    • Sonia Jimeno
    • Rosario Prados-Carvajal
    • Pablo Huertas
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15
  • Mutations in the chromatin modifier Chd7 have been associated with CHARGE syndrome and other developmental disorders. Here the authors show that Chd7 is required for the activation of genes essential for cerebellar granule cell differentiation, and that disrupting Chd7 leads to cerebellar hypoplasia in mice.

    • Weijun Feng
    • Daisuke Kawauchi
    • Hai-Kun Liu
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14