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Showing 1–9 of 9 results
Advanced filters: Author: Silvija Bilokapic Clear advanced filters

  • Set2 methyltransferase catalyzes the lysine 36 methylation of histone H3 (H3K36me) and the enzyme is mutated in many cancers. The authors provide mechanistic insights into how Set2 methylates nucleosomes by determining the 3.8 Å cryo-EM structure of Set2 bound to a H2B ubiquitinated nucleosome core particle.

    • Silvija Bilokapic
    • Mario Halic
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • The PARP2–HPF1 histone-modifying complex bridges two nucleosomes to align broken DNA ends for ligation, initiating conformational changes that activate PARP2 and enable DNA damage repair.

    • Silvija Bilokapic
    • Marcin J. Suskiewicz
    • Mario Halic
    Research
    Nature
    Volume: 585, P: 609-613

  • Binding of the human pioneer transcription factor OCT4 to nucleosomes containing endogenous DNA sequences causes changes to the nucleosome structure and facilitates the cooperative assembly of multiple pioneer transcription factors, a property that can be affected by histone modifications.

    • Kalyan K. Sinha
    • Silvija Bilokapic
    • Mario Halic
    ResearchOpen Access
    Nature
    Volume: 619, P: 378-384

  • Nucleosomes are dynamic and can move along DNA in an uncatalyzed manner but little is known about the mechanisms of histone octamer translocation. Here the authors present cryo-EM structures of nucleosomes in differently organized histone octamer and DNA states and show how histone octamers translocate DNA.

    • Silvija Bilokapic
    • Mike Strauss
    • Mario Halic
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Cryo-EM structures of nucleosomes in partially unwrapped, transient states reveal intrinsic plasticity that is required for nucleosome stability and can be exploited by chromatin-remodeling factors.

    • Silvija Bilokapic
    • Mike Strauss
    • Mario Halic
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 101-108