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Showing 1–3 of 3 results
Advanced filters: Author: Simon Alexander Mallal Clear advanced filters

  • Severe cutaneous adverse reactions (SCAR) is a T cell-mediated, potentially lethal drug hypersensitivity (DH). Here, the authors identify a carbamazepine-specific TCR common among patients with carbamazepine-induced SCAR that confers SCAR-like pathology in mice upon carbamazepine exposure, thereby implicating specific TCRs in DH etiology.

    • Ren-You Pan
    • Mu-Tzu Chu
    • Shuen-Iu Hung
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Matthew Parker et al. use the ARTIC network tiled amplicon PCR and Oxford Nanopore sequencing of thousands of SARS-CoV-2 samples to detect subgenomic RNA changes in the B.1.1.7 lineage endemic in the UK in late 2020/early 2021. They discovered higher subgenomic RNA in B.1.1.7 compared to previous lineages, and find a noncanonical subgenomic RNA that could encode ORF9b.

    • Matthew D. Parker
    • Hazel Stewart
    • Thushan I. de Silva
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-10