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Showing 1–2 of 2 results
Advanced filters: Author: Simon Bajew Clear advanced filters

  • Using massively parallel splicing assays and mathematical modeling, Bonnal et al. uncover that conserved splice site strength and exon length encode microexon sensitivity to SRRM3 and SRRM4. This work revises the switch-like splicing regulation model into a dose-responsive continuum.

    • Sophie Bonnal
    • Simon Bajew
    • Manuel Irimia
    Research
    Nature Structural & Molecular Biology
    Volume: 32, P: 2022-2034

  • In this study, Juan-Mateu et al. discover microexons that modulate insulin secretion in the pancreas in response to glucose levels in beta cell lines and mouse islets. Human genetic variants modulating these islet microexons are associated with type 2 diabetes risk.

    • Jonàs Juan-Mateu
    • Simon Bajew
    • Manuel Irimia
    Research
    Nature Metabolism
    Volume: 5, P: 219-236