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Cytomegalovirus vaccine vector-induced effector memory CD4 + T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge

Influenza genetic diversity is a key challenge in the design of a universal influenza vaccine that protects against different strains of influenza virus. Here, Malouli and colleagues demonstrate use of a cytomegalovirus-based T cell vaccine that induces immunity and can protect macaques from lethal avian influenza challenge with heterologous strains of influenza and suggest protection is linked to the generation of lung-resident influenza-specific CD4⁺ T cells.

Daniel Malouli
Meenakshi Tiwary
Jonah B. Sacha
ResearchOpen Access19 Jul 2024
Nature Communications

Volume: 15, P: 1-12
Author Correction: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

Lucy C. Walters
Karl Harlos
Geraldine M. Gillespie
Amendments and CorrectionsOpen Access13 Nov 2018
Nature Communications

Volume: 9, P: 1
Peripheral nerve stimulation for the treatment of chronic knee pain

Anton Früh
Tarik Alp Sargut
Simon Bayerl
ResearchOpen Access20 Sept 2023
Scientific Reports

Volume: 13, P: 1-9
Complex formation of APP with GABA_B receptors links axonal trafficking to amyloidogenic processing

The mechanisms that control the presynaptic abundance of GABAB receptors (GBRs) remains unclear. This study shows that sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar affinities to the N-terminal sushi-domain of presynaptic GBRs, and that selective loss of APP impaired GBR-mediated presynaptic inhibition and axonal GBR expression

Margarita C. Dinamarca
Adi Raveh
Bernhard Bettler
ResearchOpen Access22 Mar 2019
Nature Communications

Volume: 10, P: 1-17
Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

Human leucocyte antigen E (HLA-E) directly engages NK cells but also presents antigen to CD8⁺ T cells. Here the authors show crystal structures of HLA-E in complex with peptides derived from HIV and Mycobacterium tuberculosis, and describe binding conformations, the positional impact of residues involved and discuss implications for functional presentation to CD8⁺ T cells.

Lucy C. Walters
Karl Harlos
Geraldine M. Gillespie
ResearchOpen Access07 Aug 2018
Nature Communications

Volume: 9, P: 1-13
Autism-like behavior in Pianp-deficient mice is associated with decreased neuronal Erdr1 expression and altered GABA_B receptor signaling

Manuel Winkler
Siladitta Biswas
Cyrill Géraud
Research21 Oct 2020
Molecular Psychiatry

Volume: 25, P: 2645
Cryo EM structures map a post vaccination polyclonal antibody response to canine parvovirus

The polyclonal response from the serum of dogs infected with canine parvovirus is identified using cryo EM and a computational method to map the harvested Fab onto an icosahedral capsid.

Samantha R. Hartmann
Andrew J. Charnesky
Susan L. Hafenstein
ResearchOpen Access19 Sept 2023
Communications Biology

Volume: 6, P: 1-11
Pianp deficiency links GABA_B receptor signaling and hippocampal and cerebellar neuronal cell composition to autism-like behavior

Manuel Winkler
Siladitta Biswas
Cyrill Géraud
ResearchOpen Access11 Sept 2019
Molecular Psychiatry

Volume: 25, P: 2979-2993

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Cytomegalovirus vaccine vector-induced effector memory CD4 + T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge

Author Correction: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

Peripheral nerve stimulation for the treatment of chronic knee pain

Complex formation of APP with GABA_B receptors links axonal trafficking to amyloidogenic processing

Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

Autism-like behavior in Pianp-deficient mice is associated with decreased neuronal Erdr1 expression and altered GABA_B receptor signaling

Cryo EM structures map a post vaccination polyclonal antibody response to canine parvovirus

Pianp deficiency links GABA_B receptor signaling and hippocampal and cerebellar neuronal cell composition to autism-like behavior

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