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Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity

The origin of the heterogeneity of metabolic and inflammatory profiles exhibited by white adipocytes is little understood. Here, using scRNA-seq and computational methods, the authors show that differentiating preadipocytes exhibit gene expression differences and suggest underlying regulators.

Alfred K. Ramirez
Simon N. Dankel
Simon Kasif
ResearchOpen Access30 Apr 2020
Nature Communications

Volume: 11, P: 1-9
Biochemical networks: The evolution of gene annotation

Complete and accurate annotation of gene function is an essential starting point for genome interpretation and a host of systems and synthetic biology endeavors. Detecting errors in existing annotation now has an important new tool.

Simon Kasif
Martin Steffen
News & Views01 Jan 2010
Nature Chemical Biology

Volume: 6, P: 4-5
The art of gene function prediction

T M Murali
Chang-Jiun Wu
Simon Kasif
Correspondence01 Dec 2006
Nature Biotechnology

Volume: 24, P: 1474-1475
High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control

Factors underlying the effects of gastric bypass surgery on glucose homeostasis are incompletely understood. Here the authors developed and applied high-throughput mediation analysis to identify proteome/metabolome mediators of improved glucose homeostasis after to gastric bypass surgery, and report that improved glycemia was mediated by the growth hormone receptor.

Jonathan M. Dreyfuss
Yixing Yuchi
Mary Elizabeth Patti
ResearchOpen Access29 Nov 2021
Nature Communications

Volume: 12, P: 1-13
Initial sequencing and analysis of the human genome

Eric S. Lander
Lauren M. Linton
Michael J. Morgan
articles01 Feb 2001
Nature

Volume: 409, P: 860-921

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Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity

Biochemical networks: The evolution of gene annotation

The art of gene function prediction

High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control

Initial sequencing and analysis of the human genome

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