To investigate how far 3D cell culture techniques like spheroids mimic in vivo metabolism, Lagies et al. compare renal cell lines growing in conventional 2D culture and 3D spheroids with cells freshly isolated from murine kidney tissue. 3D grown cells bear many metabolic similarities to the original tissue, different from conventional 2D cell culture.
- Simon Lagies
- Manuel Schlimpert
- Lukas Peintner
