Giancarlo Abis et al. show that 15-deoxy-Δ12,14-Prostaglandin J2 inhibits the human soluble epoxide hydrolase by reversibly binding its catalytic pocket or by covalently binding reactive cysteines far from the active site. Inhibitors targeting these allosteric sites might prove to be useful therapeutic strategies.
- Giancarlo Abis
- Rebecca L. Charles
- Maria R. Conte