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Showing 1–4 of 4 results
Advanced filters: Author: Simone Di Sanzo Clear advanced filters

  • This pilot trial showed that perioperative treatment with the isocitrate dehydrogenase (IDH) inhibitor safusidenib of patients with low-grade IDH-mutant glioma, with craniotomy and lumbar puncture before and after treatment, is feasible and safe and enabled in-depth translational investigation of safusidenib treatment-induced changes in the tumor, including electrophysiological effects.

    • Katharine J. Drummond
    • Montana Spiteri
    • James R. Whittle
    ResearchOpen Access
    Nature Medicine
    P: 1-13

  • PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

    • Sarah C. Moser
    • Anna Khalizieva
    • Jos Jonkers
    Research
    Nature
    Volume: 645, P: 1071-1080

  • Accumulation of advanced glycation end products such as carboxymethyllysine (CML) has been associated with aging but their molecular roles are largely unclear. Here, the authors use proteomics to identify CML sites and show that CML formation affects protein homeostasis and cell proliferation.

    • Simone Di Sanzo
    • Katrin Spengler
    • Regine Heller
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-22