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Showing 1–4 of 4 results

Advanced filters: Author: Simone Engelender Clear advanced filters

Synphilin-1 associates with α-synuclein and promotes the formation of cytosolic inclusions

Simone Engelender
Zachary Kaminsky
Christopher A. Ross
Research01 May 1999
Nature Genetics

Volume: 22, P: 110-114
Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease

The molecular mechanism and physiological function of endoplasmic reticulum-mitochondrial contacts remain unclear. Here, authors uncover a role for the EMC2- SLC25A46-Mic19 axis in mitochondrial lipid metabolism and liver disease

Jun Dong
Li Chen
He He
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-16
Hypoxia-reprogramed megamitochondrion contacts and engulfs lysosome to mediate mitochondrial self-digestion

Several organelle membranes make contact in the cell, with many contacts being spatially segregated sites dedicated to specific functions. Here, Hao et al. show that hypoxia increases mitochondria-lysosome contacts, leading to engulfment and degradation of the mitochondria.

Tianshu Hao
Jianglong Yu
Zhiyin Song
ResearchOpen Access11 Jul 2023
Nature Communications

Volume: 14, P: 1-17
Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1

Mutations in LRRK2 are linked to Parkinson’s Disease. Here, the authors identify WSB1 as a LRRK2 interacting protein and find that it promotes LRRK2 aggregation in primary neurons and drosophila models via ubiquitin K27 and K29 linkages.

Frederick C. Nucifora Jr
Leslie G. Nucifora
Christopher A. Ross
ResearchOpen Access07 Jun 2016
Nature Communications

Volume: 7, P: 1-11