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Panos Deloukas, Nilesh Samani and colleagues report a large-scale association analysis using the Metabochip array in 63,746 coronary artery disease cases and 130,681 controls. They identify 15 susceptibility loci, refine previous associations and use network analysis to highlight biological pathways.

A cross-ancestry genome-wide association meta-analysis of amyotrophic lateral sclerosis (ALS) including 29,612 patients with ALS and 122,656 controls identifies 15 risk loci with distinct genetic architectures and neuron-specific biology.

Several natural and unnatural lissoclimide cytotoxins have been prepared via semi-synthesis and total synthesis. An X-ray co-crystal structure of chlorolissoclimide with the ribosome and evaluation of cytotoxicity and translation inhibition of new compounds in the series improves our understanding of the molecular basis for cytotoxicity.

Antibiotic resistance is a major threat across the whole healthcare spectrum. Here, the authors report on the development of biodegradable guanidinium functionalized polycarbonates and demonstrate antimicrobial activity against drug resistant infections.

African Americans have an elevated risk of developing chronic kidney disease, yet only a fraction of those with high-risk genotypes develop the disease. Here, the authors show that a missense variant in APOL1 has a strong protective effect when co-inherited with the high-risk G2 allele of APOL1, with important implications for clinical practice and translational research.

A SARS-CoV-2 variant containing a D614G substitution in the spike protein shows enhanced binding to human ACE2, increased replication in human cell cultures and a competitive advantage in animal models of infection.

A theoretical analysis of asymmetric dressed quantum dots in a photonic crystal cavity suggests that the system could form a new type of solid-state terahertz laser. However, an experimental realization will likely require advances in fabrication technology.

In lung adenocarcinoma, antibodies against endogenous retroviruses promote anti-tumour activity, and expression of endogenous retroviruses can predict outcomes of immunotherapy.

The molecular mechanisms underlying drug resistance in relapsed or refractory (rr) acute myeloid leukemia (AML) remain to be explored. Here, the use of bulk and single cell multi-omics and ex vivo drug profiling for 21 rrAML patients reveals mechanisms of resistance to the Bcl-2 inhibitor venetoclax and treatment vulnerabilities.

The immunology of Indigenous populations is generally understudied outside the context of diseases that are prevalent in these communities. Here the authors identify prevalence of influenza CD8⁺ T cell epitopes in an Indigenous Australian population expressing the susceptibility allomorph HLA A*24:02 and validate immunodominance of some of these epitopes in mice.

In Austria, policy relies on measures that promote a shift to less emission-intensive services and improve efficiency, but neglects options that reduce resource consumption, according to an analysis that combines literature review, interviews, and stakeholders’ workshops.

Transcriptomic and proteomic profiling of blood samples from individuals with COVID-19 reveals immune cell and hematopoietic progenitor cell alterations that are differentially associated with disease severity.

Bernhard Radlwimmer and colleagues report whole-genome bisulfite sequencing of 13 Burkitt lymphomas and nine follicular lymphomas. They find that both types of germinal center B cell lymphomas show global hypomethylation compared to normal germinal center B cell precursors and identify regions of differential methylation that correlate with somatic mutations and differential gene expression.

The BRICHOS domain is a chaperone that can act against amyloid-β peptide fibril formation and non-fibrillar protein aggregation. Here the authors use a multidisciplinary approach and show that the Bri2 BRICHOS domain has qualitatively different chaperone activities depending on its quaternary structure.

Cancers dependent on hedgehog pathway signaling are susceptible to the BET bromodomain inhibitor JQ1.

HDAC3 is a critical mediator of hepatic lipid metabolism and its loss leads to fatty liver. Here, the authors characterize the liver HDAC3 interactome in vivo, provide evidence that HDAC3 interacts with PROX1, and show that HDAC3 and PROX1 control expression of genes regulating lipid homeostasis.

Quantum electrodynamics predicts a rare process in which light is scattered by light. The ATLAS Collaboration reports signs of this elusive effect in the collisions of ultra-relativistic lead ions.

Long-read single-cell RNA sequencing is capable of detecting isoform-level gene expression and genomic alterations such as mutations and gene fusions, thereby providing cell-specific genotype-phenotype information. Here, the authors use long-read scRNA-seq on metastatic ovarian cancer samples and detect cell-type specific isoforms and gene fusions that may otherwise be misclassified in short-read data.

Hurricane Otis yields lessons for researchers and policymakers on how to reduce risks in the face of inequality.

TGFβ signalling through SMAD proteins controls many different processes, both during embryonic development and in adult tissues. Herhaus et al. show that the deubiquitinase OTUB1 promotes TGFβ signalling by binding specifically to activated SMAD2/3 complexes and inhibiting their ubiquitiylation.

The measurement of the total cross-section of proton–proton collisions is of fundamental importance for particle physics. Here, the first measurement of the inelastic cross-section is presented for proton–proton collisions at an energy of 7 teraelectronvolts using the ATLAS detector at the Large Hadron Collider.

Cavitation refers to the emergence of bubbles from liquids undergoing pressure reduction. A hitherto unknown cavitation scenario is now reported, with bubbles originating from the atomically smooth interface between two immiscible liquids.

Ephemeral snow and ice melt contribute substantially to dry season runoff in the Rio Santa basin, with snowmelt accounting for up to 55% and ice melt up to 44% of inputs, according to results from a distributed glacio-hydrological model applied to quantify cryospheric contributions to the Andean water cycle.

Analysis of clinically approved antibody-based therapeutics reveals different structural designs, such as full-length IgG1 or Fc-fusions, entail distinct biophysical properties that affect FcRn binding, intracellular transport and plasma half-life.

Overgrowth of cellular microtubules (MTs) is associated with a range of disease processes. Cellular and biophysical reconstitution experiments reveal that estradiol transforms dynamic, growing MTs into paused, non-growing MTs.

Artificial intelligence (AI) is becoming more and more common in people’s lives. Here, the authors use an expert elicitation method to understand how AI may affect the achievement of the Sustainable Development Goals.

Thermo-optically induced transparency is a versatile implementation of EIT-analogs in an integrated photonic platform, at arbitrary wavelength of interest, room temperature and in a practical, low cost, and scalable system.