Nature Search

Stop-and-go kinetics in amyloid fibrillation

Jesper Ferkinghoff-Borg
Jesper Fonslet
Mogens Jensen
ResearchOpen Access15 Mar 2010
Nature Precedings

P: 1
Enhanced non-classical electrostriction in strained tetragonal ceria

Non-classical electrostriction in fluorites arises from defect-induced polarization and lattice distortions. This study shows that mismatch strain in Gd-doped CeO₂ thin films fine-tunes electromechanical responses, achieving high electrostriction above 10−¹⁵ m²V⁻².

Simone Santucci
Milica Vasiljevic
Vincenzo Esposito
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-11
Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria

Antibody based biologics are a rapidly growing class of therapeutics with interest to enhance their performance, distribution, longevity and effectivity. Here, authors report the engineering of human IgG Fc to enhance plasma half-life, mucosal distribution and killing of cancer cells and bacteria.

Stian Foss
Siri A. Sakya
Jan Terje Andersen
ResearchOpen Access07 Mar 2024
Nature Communications

Volume: 15, P: 1-16
Human heart-forming organoids recapitulate early heart and foregut development

Heart-forming organoids model early cardiac development.

Lika Drakhlis
Santoshi Biswanath
Robert Zweigerdt
ResearchOpen Access08 Feb 2021
Nature Biotechnology

Volume: 39, P: 737-746
Isoprene nitrates drive new particle formation in Amazon’s upper troposphere

Aircraft measurements over the Amazon show that new particle formation in the upper troposphere emerges when isoprene, emitted by forests, undergoes oxidation in the presence of nitrogen oxides produced by lightning.

Joachim Curtius
Martin Heinritzi
Jos Lelieveld
ResearchOpen Access04 Dec 2024
Nature

Volume: 636, P: 124-130
Entropy-driven formation of large icosahedral colloidal clusters by spherical confinement

Experiments with colloidal nano- and microparticles and computer simulations show that, unexpectedly, confinement and entropy are sufficient for the formation of icosahedral crystalline clusters of up to about 100,000 particles.

Bart de Nijs
Simone Dussi
Marjolein Dijkstra
Research31 Aug 2014
Nature Materials

Volume: 14, P: 56-60
Long-term decline of global atmospheric ethane concentrations and implications for methane

The longest continuous record of global atmospheric ethane levels is presented, showing that global ethane emission rates decreased by 21 per cent from 1984 to 2010, probably owing to decreased venting and flaring of natural gas in oil fields; decreased venting and flaring also account for at least 30 to 70 per cent of the decrease in methane emissions over the same period.

Isobel J. Simpson
Mads P. Sulbaek Andersen
Donald R. Blake
Research22 Aug 2012
Nature

Volume: 488, P: 490-494
The globalizability of temporal discounting

Ruggeri et al. find in a study of 61 countries that temporal discounting patterns are globally generalizable. Worse financial environments, greater inequality and high inflation are associated with extreme or inconsistent long-term decisions.

Kai Ruggeri
Amma Panin
Eduardo García-Garzon
ResearchOpen Access11 Jul 2022
Nature Human Behaviour

Volume: 6, P: 1386-1397
Variants in the WDR44 WD40-repeat domain cause a spectrum of ciliopathy by impairing ciliogenesis initiation

A vesicle trafficking Rab11 effector switch is important for ciliogenesis. Here, the authors report a ciliopathy-related disorder caused by variants in WDR44, a Rab11 effector. WDR44 variants show higher affinity for Rab11 and can impair ciliogenesis.

Andrea Accogli
Saurabh Shakya
Christopher J. Westlake
ResearchOpen Access08 Jan 2024
Nature Communications

Volume: 15, P: 1-20
Large-scale comparative metagenomics of Blastocystis, a common member of the human gut microbiome

Francesco Beghini
Edoardo Pasolli
Nicola Segata
ResearchOpen Access22 Aug 2017
The ISME Journal

Volume: 11, P: 2848-2863
Author Correction: Isoprene nitrates drive new particle formation in Amazon’s upper troposphere

Joachim Curtius
Martin Heinritzi
Jos Lelieveld
Amendments and CorrectionsOpen Access01 Apr 2025
Nature

Volume: 640, P: E30
T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection

Analysis of peripheral mycobacteria-reactive CD4⁺ T cell receptor sequences from individuals infected with Mycobacterium tuberculosis shows a high degree of overlap between progressors and controllers, but points to some distinct clonotypes that are enriched in either group.

Munyaradzi Musvosvi
Huang Huang
Tran Van
ResearchOpen Access05 Jan 2023
Nature Medicine

Volume: 29, P: 258-269
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

A cross-ancestry genome-wide association meta-analysis of amyotrophic lateral sclerosis (ALS) including 29,612 patients with ALS and 122,656 controls identifies 15 risk loci with distinct genetic architectures and neuron-specific biology.

Wouter van Rheenen
Rick A. A. van der Spek
Jan H. Veldink
ResearchOpen Access06 Dec 2021
Nature Genetics

Volume: 53, P: 1636-1648
Bacteria are important dimethylsulfoniopropionate producers in coastal sediments

Bacterial dimethylsulfoniopropionate (DMSP) production was recently demonstrated in surface oceans. Here the authors show that bacterial production is higher in sediment from coastal areas and the deep ocean, and identify an alternative pathway for its synthesis, indicating that coastal and marine sediments are important sources of this climate-relevant metabolite.

Beth T. Williams
Kasha Cowles
Jonathan D. Todd
Research19 Aug 2019
Nature Microbiology

Volume: 4, P: 1815-1825
Vulnerability of the North Water ecosystem to climate change

The North Water polynya is a unique but vulnerable ecosystem, home to Indigenous people and Arctic keystone species. New palaeoecological records from Greenland suggest human abandonment c. 2200–1200 cal yrs BP occurred during climate-forced polynya instability, foreshadowing future ecosystem declines.

Sofia Ribeiro
Audrey Limoges
Thomas A. Davidson
ResearchOpen Access22 Jul 2021
Nature Communications

Volume: 12, P: 1-12
Cytotoxic T cells isolated from healthy donors and cancer patients kill TGFβ-expressing cancer cells in a TGFβ-dependent manner

Morten Orebo Holmström
Rasmus Erik Johansson Mortensen
Mads Hald Andersen
Research06 Jan 2021
Cellular & Molecular Immunology

Volume: 18, P: 415-426
A framework for human microbiome research

The Human Microbiome Project Consortium has established a population-scale framework to study a variety of microbial communities that exist throughout the human body, enabling the generation of a range of quality-controlled data as well as community resources.

Barbara A. Methé
Karen E. Nelson
Owen White
ResearchOpen Access13 Jun 2012
Nature

Volume: 486, P: 215-221
The molecular origin and taxonomy of mucinous ovarian carcinoma

Whether mucinous ovarian carcinoma (MOC) arises from cells at the ovary or from metastases from other primary sites is an unanswered question. Here, Cheasley et al perform a genetic analysis of the disease, showing that MOC arises at the ovary.

Dane Cheasley
Matthew J. Wakefield
Kylie L. Gorringe
ResearchOpen Access02 Sept 2019
Nature Communications

Volume: 10, P: 1-11
eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells

It has been suggested that nonsense-mediated mRNA decay (NMD) is restricted to cap-binding complex (CBC)-bound mRNAs during the pioneer round of translation in mammalian cells. However, analysis of the decay kinetics of mRNAs bound to either CBC or the eukaryotic initiation factor 4E in human cells shows that both substrate types are equally susceptible to NMD.

Simone C Rufener
Oliver Mühlemann
Research12 May 2013
Nature Structural & Molecular Biology

Volume: 20, P: 710-717
Melting line of calcium characterized by in situ LH-DAC XRD and first-principles calculations

Simone Anzellini
Dario Alfé
Daniel Errandonea
ResearchOpen Access22 Jul 2021
Scientific Reports

Volume: 11, P: 1-9
Structure, function and diversity of the healthy human microbiome

The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.

Curtis Huttenhower
Dirk Gevers
Owen White
ResearchOpen Access13 Jun 2012
Nature

Volume: 486, P: 207-214
High frequencies of circulating memory T cells specific for calreticulin exon 9 mutations in healthy individuals

Morten O. Holmström
Shamaila M. Ahmad
Mads H. Andersen
ResearchOpen Access17 Jan 2019
Blood Cancer Journal

Volume: 9, P: 1-14
Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life

Analysis of clinically approved antibody-based therapeutics reveals different structural designs, such as full-length IgG1 or Fc-fusions, entail distinct biophysical properties that affect FcRn binding, intracellular transport and plasma half-life.

Torleif Tollefsrud Gjølberg
Rahel Frick
Jan Terje Andersen
ResearchOpen Access18 Aug 2022
Communications Biology

Volume: 5, P: 1-17
Metabolite changes in blood predict the onset of tuberculosis

The tuberculosis pandemic requires new methods for diagnosing and containing infections prior to active disease. Here, the authors performed a multi-site observational study within sub-Saharan Africa and present serum and plasma metabolic signatures that can predict the onset of active TB with a high degree of sensitivity and specificity.

January Weiner 3rd
Jeroen Maertzdorf
Sarah Zalwango
ResearchOpen Access06 Dec 2018
Nature Communications

Volume: 9, P: 1-12
Synthetic oligonucleotide antigens modified with locked nucleic acids detect disease specific antibodies

Simone V. Samuelsen
Ilia A. Solov’yov
Kira Astakhova
ResearchOpen Access24 Oct 2016
Scientific Reports

Volume: 6, P: 1-12
CUX1-related neurodevelopmental disorder: deep insights into phenotype-genotype spectrum and underlying pathology

Henry Oppermann
Elia Marcos-Grañeda
Konrad Platzer
ResearchOpen Access30 Aug 2023
European Journal of Human Genetics

Volume: 31, P: 1251-1260
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

Ammar Al-Chalabi, Jan Veldink and colleagues perform a genome-wide association study for amyotrophic lateral sclerosis (ALS) in 15,156 cases and 26,242 controls. They identify three new genome-wide-significant variants and establish ALS as a complex trait with a polygenic architecture, but with a distinct and important role for low-frequency variants.

Wouter van Rheenen
Aleksey Shatunov
Jan H Veldink
Research25 Jul 2016
Nature Genetics

Volume: 48, P: 1043-1048
Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling

Kristine Pettersen
Sonja Andersen
Geir Bjørkøy
ResearchOpen Access17 May 2017
Scientific Reports

Volume: 7, P: 1-16
Hormonal and biochemical changes in female Proechimys guyannensis, an animal model of resistance to pilocarpine-induced status epilepticus

Viviam Sanabria
Simone Bittencourt
Débora Amado
ResearchOpen Access02 Dec 2020
Scientific Reports

Volume: 10, P: 1-14
Fertility preservation in boys facing gonadotoxic cancer therapy

Treatment for childhood cancer can cause infertility in patients who survive to adulthood. Jensen et al. discuss the options for fertility preservation in pre-pubertal and pubertal boys, covering preservation of spermatozoa and testis tissue, as well as psychological and ethical issues, and current challenges to fertility preservation.

Christian F. S. Jensen
Lihua Dong
Jens Sønksen
Reviews19 Oct 2021
Nature Reviews Urology

Volume: 19, P: 71-83
The International Climate Psychology Collaboration: Climate change-related data collected from 63 countries

Kimberly C. Doell
Boryana Todorova
Jay J. Van Bavel
ResearchOpen Access01 Oct 2024
Scientific Data

Volume: 11, P: 1-17
The Src family kinase inhibitor dasatinib delays pain-related behaviour and conserves bone in a rat model of cancer-induced bone pain

Camilla Kristine Appel
Simone Gallego-Pedersen
Anne-Marie Heegaard
ResearchOpen Access06 Jul 2017
Scientific Reports

Volume: 7, P: 1-14
Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Wouter van Rheenen
Rick A. A. van der Spek
Jan H. Veldink
Amendments and CorrectionsOpen Access31 Jan 2022
Nature Genetics

Volume: 54, P: 361
Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

Eun Young Kang
Dane Cheasley
Kylie L. Gorringe
Research28 Jul 2020
Modern Pathology

Volume: 34, P: 194-206
RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

Adam Penn-Nicholson
Stanley Kimbung Mbandi
Lara Lewis
ResearchOpen Access25 May 2020
Scientific Reports

Volume: 10, P: 1-21
Asporin is a stromally expressed marker associated with prostate cancer progression

Annie Rochette
Nadia Boufaied
Axel A Thomson
ResearchOpen Access02 Feb 2017
British Journal of Cancer

Volume: 116, P: 775-784

Search

Stop-and-go kinetics in amyloid fibrillation

Enhanced non-classical electrostriction in strained tetragonal ceria

Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria

Human heart-forming organoids recapitulate early heart and foregut development

Isoprene nitrates drive new particle formation in Amazon’s upper troposphere

Entropy-driven formation of large icosahedral colloidal clusters by spherical confinement

Long-term decline of global atmospheric ethane concentrations and implications for methane

The globalizability of temporal discounting

Variants in the WDR44 WD40-repeat domain cause a spectrum of ciliopathy by impairing ciliogenesis initiation

Large-scale comparative metagenomics of Blastocystis, a common member of the human gut microbiome

Author Correction: Isoprene nitrates drive new particle formation in Amazon’s upper troposphere

T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Bacteria are important dimethylsulfoniopropionate producers in coastal sediments

Vulnerability of the North Water ecosystem to climate change

Cytotoxic T cells isolated from healthy donors and cancer patients kill TGFβ-expressing cancer cells in a TGFβ-dependent manner

A framework for human microbiome research

The molecular origin and taxonomy of mucinous ovarian carcinoma

eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells

Melting line of calcium characterized by in situ LH-DAC XRD and first-principles calculations

Structure, function and diversity of the healthy human microbiome

High frequencies of circulating memory T cells specific for calreticulin exon 9 mutations in healthy individuals

Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life

Metabolite changes in blood predict the onset of tuberculosis

Synthetic oligonucleotide antigens modified with locked nucleic acids detect disease specific antibodies

CUX1-related neurodevelopmental disorder: deep insights into phenotype-genotype spectrum and underlying pathology

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling

Hormonal and biochemical changes in female Proechimys guyannensis, an animal model of resistance to pilocarpine-induced status epilepticus

Fertility preservation in boys facing gonadotoxic cancer therapy

The International Climate Psychology Collaboration: Climate change-related data collected from 63 countries

The Src family kinase inhibitor dasatinib delays pain-related behaviour and conserves bone in a rat model of cancer-induced bone pain

Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

Asporin is a stromally expressed marker associated with prostate cancer progression

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