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The microbial metabolite imidazole propionate dysregulates bone homeostasis by inhibiting AMP-activated protein kinase (AMPK) signaling

Imidazole propionate, a microbial metabolite, impairs bone homeostasis by inhibiting osteoblast differentiation and enhancing adipocyte differentiation via p38γ activation and AMPK suppression. Metformin counters these effects.

Suk-Gyun Park
Jung-Woo Kim
Jeong-Tae Koh
ResearchOpen Access19 Dec 2024
Communications Biology

Volume: 7, P: 1-12
CUEDC2 controls osteoblast differentiation and bone formation via SOCS3–STAT3 pathway

Jung-Woo Kim
Sin-Hye Oh
Jeong-Tae Koh
ResearchOpen Access11 May 2020
Cell Death & Disease

Volume: 11, P: 1-13
Elevated extracellular calcium ions promote proliferation and migration of mesenchymal stem cells via increasing osteopontin expression

Mi Nam Lee
Hee-Su Hwang
Jeong-Tae Koh
ResearchOpen Access05 Nov 2018
Experimental & Molecular Medicine

Volume: 50, P: 1-16