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Global emergence of a hypervirulent carbapenem-resistant Escherichia coli ST410 clone

In this work, the authors identified a hypervirulent carbapenem-resistant Escherichia coli ST410 clone which carries a high pathogenicity island and an O-antigen gene cluster. The findings highlight the ongoing evolution of ST410 towards increased resistance and virulence.

Xiaoliang Ba
Yingyi Guo
Chao Zhuo
ResearchOpen Access12 Jan 2024
Nature Communications

Volume: 15, P: 1-15
Delay guaranteed SFC placement with VNF parallelization in multidomain IoT networks

Siquan Liu
Chuangchuang Zhang
Xingwei Wang
ResearchOpen Access13 Nov 2025
Scientific Reports

Volume: 15, P: 1-18
PDLIM1 inhibits cell migration and invasion in diabetic retinopathy via negatively regulating Wnt3a

Pinxue Xie
Qisheng You
Xinxiao Gao
ResearchOpen Access10 Apr 2023
Scientific Reports

Volume: 13, P: 1-8
The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma

CX-5461 recently progressed through phase I clinical trial as a first-inhuman inhibitor of RNA-POL I. Here, the authors demonstrate that CX-5461 synergizes with topoisomerase I inhibitors to inhibit neuroblastoma cells and that its primary target in this disease is topoisomerase II beta and not RNA-POL I.

Min Pan
William C. Wright
Paul Geeleher
ResearchOpen Access09 Nov 2021
Nature Communications

Volume: 12, P: 1-20
6mer seed toxicity in tumor suppressive microRNAs

Small interfering (siRNAs) can be toxic to cancer cells. Here the authors investigate the toxicity of microRNA in cancer cells by performing a siRNA screen that tests the miRNA activities of an extensive list of miRNAs with different 6mer seed sequences.

Quan Q. Gao
William E. Putzbach
Marcus E. Peter
ResearchOpen Access29 Oct 2018
Nature Communications

Volume: 9, P: 1-16
Epidemical and etiological study on hand, foot and mouth disease following EV-A71 vaccination in Xiangyang, China

Xiao-Dan Meng
Yeqing Tong
Shuo Shen
ResearchOpen Access01 Dec 2020
Scientific Reports

Volume: 10, P: 1-11

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Global emergence of a hypervirulent carbapenem-resistant Escherichia coli ST410 clone

Delay guaranteed SFC placement with VNF parallelization in multidomain IoT networks

PDLIM1 inhibits cell migration and invasion in diabetic retinopathy via negatively regulating Wnt3a

The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma

6mer seed toxicity in tumor suppressive microRNAs

Epidemical and etiological study on hand, foot and mouth disease following EV-A71 vaccination in Xiangyang, China

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