Nature Search

Complex activity and short-term plasticity of human cerebral organoids reciprocally connected with axons

Connecting cerebral organoids with an axon bundle models inter-regional projections and enhances neural activity. Optogenetic stimulation induces short-term plasticity, offering insights into macroscopic circuit development and functionality.

Tatsuya Osaki
Tomoya Duenki
Yoshiho Ikeuchi
ResearchOpen Access10 Apr 2024
Nature Communications

Volume: 15, P: 1-13
Calibrated ribosome profiling assesses the dynamics of ribosomal flux on transcripts

Ribosome profiling faces issues with rRNA contamination and measurements of ribosome numbers on transcripts. Here, the authors develop Ribo-FilterOut and Ribo-Calibration, methods which can be used to estimate kinetic and stoichiometric parameters of translation under various conditions.

Kotaro Tomuro
Mari Mito
Shintaro Iwasaki
ResearchOpen Access26 Aug 2024
Nature Communications

Volume: 15, P: 1-17
dCas13-mediated translational repression for accurate gene silencing in mammalian cells

Current gene silencing tools can have drawbacks. Here the authors report CRISPRδ, an approach for translational silencing, harnessing catalytically inactive Cas13 proteins (dCas13): they also show that fusion of a translational repressor to dCas13 further improved the performance.

Antonios Apostolopoulos
Naohiro Kawamoto
Shintaro Iwasaki
ResearchOpen Access11 Mar 2024
Nature Communications

Volume: 15, P: 1-18
Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

The genomic characterisation of nasopharyngeal carcinoma (NPC) remains crucial. Here, the authors perform whole-genome sequencing for 70 NPCs with EBV gene expression, report the somatic alterations and EBV-mediated effects converging on NF-κB activation and immune escape and identify targetable homozygous MTAP deletions.

Jeff P. Bruce
Ka-Fai To
Kwok-Wai Lo
ResearchOpen Access07 Jul 2021
Nature Communications

Volume: 12, P: 1-15
Author Correction: Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

Jeff P. Bruce
Ka-Fai To
Kwok-Wai Lo
Amendments and CorrectionsOpen Access27 Jul 2022
Nature Communications

Volume: 13, P: 1
Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy

Zaijun Zhang
Gaoxiao Zhang
Yuqiang Wang
ResearchOpen Access14 Nov 2016
Scientific Reports

Volume: 6, P: 1-10
Intradermal vaccination of live attenuated influenza vaccine protects mice against homologous and heterologous influenza challenges

Andrew Chak-Yiu Lee
Anna Jinxia Zhang
Kwok-Yung Yuen
ResearchOpen Access04 Aug 2021
npj Vaccines

Volume: 6, P: 1-13
Accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloading

Dandan Yao et al. demonstrated that accumulation of formaldehyde in the cerebellum and skeletal muscle contributed toward motor deficits in a mouse model of hindlimb unloading. Their results collectively suggest that scavenging formaldehyde may be a useful treatment to limit motor dysfunction following limb offloading conditions.

Dandan Yao
Qingyuan He
Zhiqian Tong
ResearchOpen Access19 Aug 2021
Communications Biology

Volume: 4, P: 1-13
Correction: Corrigendum: NPNT is Expressed by Osteoblasts and Mediates Angiogenesis via the Activation of Extracellular Signal-regulated Kinase

Vincent Kuek
Zhifan Yang
Jiake Xu
Amendments and CorrectionsOpen Access21 Nov 2016
Scientific Reports

Volume: 6, P: 1
The acceptance of ophthalmic artificial intelligence for eye diseases: a literature review and qualitative analysis

An Ran Ran
Chun Ho Lui
Carol Y. Cheung
Reviews13 Jun 2025
Eye

Volume: 39, P: 2353-2362
Obestatin and growth hormone reveal the interaction of central obesity and other cardiometabolic risk factors of metabolic syndrome

Angus P. Yu
Felix N. Ugwu
Parco M. Siu
ResearchOpen Access26 Mar 2020
Scientific Reports

Volume: 10, P: 1-10
NPNT is Expressed by Osteoblasts and Mediates Angiogenesis via the Activation of Extracellular Signal-regulated Kinase

Vincent Kuek
Zhifan Yang
Jiake Xu
ResearchOpen Access26 Oct 2016
Scientific Reports

Volume: 6, P: 1-13
Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis

Debra Van Egeren
Khushi Kohli
Zenta Walther
ResearchOpen Access09 Nov 2022
Scientific Reports

Volume: 12, P: 1-6

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Complex activity and short-term plasticity of human cerebral organoids reciprocally connected with axons

Calibrated ribosome profiling assesses the dynamics of ribosomal flux on transcripts

dCas13-mediated translational repression for accurate gene silencing in mammalian cells

Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

Author Correction: Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy

Intradermal vaccination of live attenuated influenza vaccine protects mice against homologous and heterologous influenza challenges

Accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloading

Correction: Corrigendum: NPNT is Expressed by Osteoblasts and Mediates Angiogenesis via the Activation of Extracellular Signal-regulated Kinase

The acceptance of ophthalmic artificial intelligence for eye diseases: a literature review and qualitative analysis

Obestatin and growth hormone reveal the interaction of central obesity and other cardiometabolic risk factors of metabolic syndrome

NPNT is Expressed by Osteoblasts and Mediates Angiogenesis via the Activation of Extracellular Signal-regulated Kinase

Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis

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