Nature Search

Whole-body CD8⁺ T cell visualization before and during cancer immunotherapy: a phase 1/2 trial

A CD8-specific, one-armed antibody positron emission tomography tracer enables the visualization of the immune response in patients with solid tumors before and after starting immunotherapy.

Laura Kist de Ruijter
Pim P. van de Donk
Elisabeth G. E. de Vries
ResearchOpen Access05 Dec 2022
Nature Medicine

Volume: 28, P: 2601-2610
Polymorphism for a 1.6-Mb deletion of the human Y chromosome persists through balance between recurrent mutation and haploid selection

Sjoerd Repping
Helen Skaletsky
Steve Rozen
Research05 Oct 2003
Nature Genetics

Volume: 35, P: 247-251
Nuclear chromosome locations dictate segregation error frequencies

Using single-cell DNA sequencing after an error-prone mitosis in untransformed, diploid cell lines and organoids, chromosomes are shown to have different segregation error frequencies that result in non-random aneuploidy landscapes.

Sjoerd J. Klaasen
My Anh Truong
Geert J. P. L. Kops
ResearchOpen Access13 Jul 2022
Nature

Volume: 607, P: 604-609
The HADDOCK web server for data-driven biomolecular docking

Sjoerd J de Vries
Marc van Dijk
Alexandre M J J Bonvin
Protocols15 Apr 2010
Nature Protocols

Volume: 5, P: 883-897
Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

The authors use three-dimensional live-cell imaging of colorectal carcinoma organoids to show that chromosomal instability is widespread. Single-cell sequencing identifies heterogeneity of copy number alterations and shows clonal evolution.

Ana C. F. Bolhaqueiro
Bas Ponsioen
Geert J. P. L. Kops
Research29 Apr 2019
Nature Genetics

Volume: 51, P: 824-834
Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

The molecular and cellular causes of glaucoma are not well understood. Here, the authors integrate GWAS with genetic regulation and single cell expression from multiple eye tissues to identify genes and key cell types that affect glaucoma pathogenesis.

Andrew R. Hamel
Wenjun Yan
Ayellet V. Segrè
ResearchOpen Access09 Jan 2024
Nature Communications

Volume: 15, P: 1-25
Development of radiomics-based models on mammograms with mass lesions to predict prognostically relevant characteristics of invasive breast cancer in a screening cohort

Jim Peters
Merle M. van Leeuwen
Mireille J. M. Broeders
Research06 Apr 2025
British Journal of Cancer

Volume: 132, P: 1040-1049
Fuelling conditions at staging sites can mitigate Arctic warming effects in a migratory bird

Advancing phenological timing is a risk for migratory birds, particularly in the Arctic where change is most rapid. Here, the authors show that bar-tailed godwits can adjust for phenological shifts by fuelling faster at staging areas to arrive at breeding sites in time.

Eldar Rakhimberdiev
Sjoerd Duijns
Theunis Piersma
ResearchOpen Access15 Oct 2018
Nature Communications

Volume: 9, P: 1-10
High mutation rates have driven extensive structural polymorphism among human Y chromosomes

Sjoerd Repping
Saskia K M van Daalen
Steve Rozen
Research26 Feb 2006
Nature Genetics

Volume: 38, P: 463-467
⁸⁹Zr-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer

Initial results from a first-in-human study show that PET imaging with PD-L1 antibodies outperforms immunohistochemistry- or RNA-sequencing-based biomarkers for prediction of clinical response to immunotherapy.

Frederike Bensch
Elly L. van der Veen
Elisabeth G. E. de Vries
Research26 Nov 2018
Nature Medicine

Volume: 24, P: 1852-1858
Integrating molecular nuclear imaging in clinical research to improve anticancer therapy

Integrating molecular nuclear imaging in clinical research has great potential to improve anticancer therapy, particularly through the development of imaging biomarkers. Herein, the multistage process of developing novel molecular imaging biomarkers is discussed, highlighting both the challenges that have restricted the use of molecular imaging in clinical oncology research and future opportunities in this area.

Elisabeth G. E. de Vries
Laura Kist de Ruijter
Sjoukje F. Oosting
Reviews27 Nov 2018
Nature Reviews Clinical Oncology

Volume: 16, P: 241-255
DaReUS-Loop: accurate loop modeling using fragments from remote or unrelated proteins

Yasaman Karami
Frédéric Guyon
Pierre Tufféry
ResearchOpen Access12 Sept 2018
Scientific Reports

Volume: 8, P: 1-12
CD4⁺ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors

Xin Lei
Daniël C. de Groot
Yanling Xiao
ResearchOpen Access21 Feb 2024
Cellular & Molecular Immunology

Volume: 21, P: 374-392
Loss of H3K27 tri-methylation is a diagnostic marker for malignant peripheral nerve sheath tumors and an indicator for an inferior survival

Arjen H G Cleven
Ghadah A Al Sannaa
Judith V M G Bovée
Research18 Mar 2016
Modern Pathology

Volume: 29, P: 582-590
Erratum: Loss of H3K27 tri-methylation is a diagnostic marker for malignant peripheral nerve sheath tumors and an indicator for an inferior survival

Arjen HG Cleven
Ghadah A Al Sannaa
Judith VMG Bovée
Amendments and Corrections30 Aug 2016
Modern Pathology

Volume: 29, P: 1113
High expression of secretory leukocyte protease inhibitor (SLPI) in stage III micro-satellite stable colorectal cancer is associated with reduced disease recurrence

Sandrine Nugteren
Sjoerd H. den Uil
Janneke N. Samsom
ResearchOpen Access16 Jul 2022
Scientific Reports

Volume: 12, P: 1-10

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