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Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content

Little is known about the recent evolution of the Y chromosome because only the human Y chromosome has been fully sequenced. The sequencing of the male-specific region of the Y chromosome (MSY) in the chimpanzee and comparison between the MSYs of the two species now reveals that they differ radically in sequence structure and gene content, indicating rapid evolution over the past 6 million years.

Jennifer F. Hughes
Helen Skaletsky
David C. Page
Research13 Jan 2010
Nature

Volume: 463, P: 536-539
High mutation rates have driven extensive structural polymorphism among human Y chromosomes

Sjoerd Repping
Saskia K M van Daalen
Steve Rozen
Research26 Feb 2006
Nature Genetics

Volume: 38, P: 463-467
Polymorphism for a 1.6-Mb deletion of the human Y chromosome persists through balance between recurrent mutation and haploid selection

Sjoerd Repping
Helen Skaletsky
Steve Rozen
Research05 Oct 2003
Nature Genetics

Volume: 35, P: 247-251
Multiple meiotic errors caused by predivision of chromatids in women of advanced maternal age undergoing in vitro fertilisation

Alan H Handyside
Markus Montag
Joep Geraedts
Research08 Feb 2012
European Journal of Human Genetics

Volume: 20, P: 742-747
The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes

Helen Skaletsky
Tomoko Kuroda-Kawaguchi
David C. Page
Research19 Jun 2003
Nature

Volume: 423, P: 825-837
Massive expression of germ cell-specific genes is a hallmark of cancer and a potential target for novel treatment development

Jan Willem Bruggeman
Jan Koster
Geert Hamer
ResearchOpen Access15 Jun 2018
Oncogene

Volume: 37, P: 5694-5700
Female subfertility

Subfertility affects one in six couples worldwide and is associated with emotional distress and reduced quality of life. This Primer by Farquhar and colleagues discusses the causes, diagnosis and treatment of female subfertility.

Cynthia M. Farquhar
Siladitya Bhattacharya
Jacky Boivin
Reviews24 Jan 2019
Nature Reviews Disease Primers

Volume: 5, P: 1-21

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Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content

High mutation rates have driven extensive structural polymorphism among human Y chromosomes

Polymorphism for a 1.6-Mb deletion of the human Y chromosome persists through balance between recurrent mutation and haploid selection

Multiple meiotic errors caused by predivision of chromatids in women of advanced maternal age undergoing in vitro fertilisation

The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes

Massive expression of germ cell-specific genes is a hallmark of cancer and a potential target for novel treatment development

Female subfertility

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