Artificial nucleic acids with a fixed conformation of the backbone of the oligonucleotide can form stable duplexes, however, the synthesis of modified nucleotides with non-canonical three-dimensional structures remains very challenging. Here, the authors design and synthesize dinucleotides containing 2′,3′-trans-bridged nucleic acids (2′,3′-trans-BNAs), showing a similar N-type sugar conformation in RNA-duplex but with different ζ and α torsion angles.
- Takashi Osawa
- Ryota Nakanishi
- Satoshi Obika
