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Genetic regulation of post-translational modification of two distinct proteins

Post-translational modifications are known to diversify protein functions, but the effect of genetic variation on the modifications is not well known. Here, the authors find both shared and protein-specific genetic mechanisms regulating the glycosylation of two different proteins.

Arianna Landini
Irena Trbojević-Akmačić
Lucija Klarić
ResearchOpen Access24 Mar 2022
Nature Communications

Volume: 13, P: 1-13
A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins

Proteins are often modified by complex carbohydrates (N-glycans). Here, authors identified gene regulators of this process and uncovered links between plasma protein Nglycosylation, metabolic and liver diseases, and anti-inflammatory proteins.

Sodbo Sharapov
Anna Timoshchuk
Yurii S. Aulchenko
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-17
The genetic landscape of neuro-related proteins in human plasma

Repetto et al. provide an analysis of the genetic basis of variation of neuro-related protein levels in plasma and link this to human behaviour and disorders.

Linda Repetto
Jiantao Chen
Xia Shen
Research29 Aug 2024
Nature Human Behaviour

Volume: 8, P: 2222-2234
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification

Genome-wide association analyses of blood glucose measurements under nonstandardized conditions provide insights into the biology of glucose regulation, diabetes complications and pathways for treatment stratification.

Vasiliki Lagou
Longda Jiang
Cornelia M. van Duijn
ResearchOpen Access07 Sept 2023
Nature Genetics

Volume: 55, P: 1448-1461
Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation

Multivariate analysis methods can uncover the relationship between phenotypic measures characterised by modern omic techniques. Here the authors conduct a multivariate GWAS on IgG N-glycosylation phenotypes and identify 5 novel loci enriched in immune system genes.

Xia Shen
Lucija Klarić
Yurii S. Aulchenko
ResearchOpen Access06 Sept 2017
Nature Communications

Volume: 8, P: 1-10
Analysis of genetically independent phenotypes identifies shared genetic factors associated with chronic musculoskeletal pain conditions

Yakov Tsepilov, Maxim Freidin et al. find that chronic musculoskeletal pain conditions at four distinct anatomical sites share a common genetic background. The authors constructed genetically independent phenotypes (GIP) from principal components analysis of the different pain phenotypes and used the GIPs to perform genome-wide association studies to identify underlying genetic factors.

Yakov A. Tsepilov
Maxim B. Freidin
Yurii S. Aulchenko
ResearchOpen Access25 Jun 2020
Communications Biology

Volume: 3, P: 1-13
Prioritization of causal genes for coronary artery disease based on cumulative evidence from experimental and in silico studies

Alexandra S. Shadrina
Tatiana I. Shashkova
Yurii S. Aulchenko
ResearchOpen Access26 Jun 2020
Scientific Reports

Volume: 10, P: 1-15
Identification of 12 genetic loci associated with human healthspan

Aleksandr Zenin et al. present a genome-wide association study and genetic risk model for human healthspan, the length of morbidity-free life. They identify 12 loci associated with healthspan and osbserve genetic correlations between healthspan and life-history and lifestyle traits, such as obesity and smoking.

Aleksandr Zenin
Yakov Tsepilov
Yurii Aulchenko
ResearchOpen Access30 Jan 2019
Communications Biology

Volume: 2, P: 1-11

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Genetic regulation of post-translational modification of two distinct proteins

A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins

The genetic landscape of neuro-related proteins in human plasma

GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification

Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation

Analysis of genetically independent phenotypes identifies shared genetic factors associated with chronic musculoskeletal pain conditions

Prioritization of causal genes for coronary artery disease based on cumulative evidence from experimental and in silico studies

Identification of 12 genetic loci associated with human healthspan

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