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Several groups of LysM-RLKs are involved in symbiotic signal perception and arbuscular mycorrhiza establishment

A group of plant receptor-like kinases (LysM-RLKs) with high affinity for short-chain chitooligosaccharides and lipo-chitooligosaccharides (LCOs), play a complementary role in arbuscular mycorrhiza establishment with a sister group of LysM-RLKs specifically recognising LCOs.

Yi Ding
Zélie Lesterps
Benoit Lefebvre
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-14
Illumination of a progressive allosteric mechanism mediating the glycine receptor activation

Glycine receptors are channel receptors mediating signal transduction between neurons that transit between resting and open states upon neurotransmitter binding. Here, the authors illuminate a progressive transition of opening by combining voltage-clamp fluorometry and molecular dynamics.

Sophie Shi
Solène N. Lefebvre
Pierre-Jean Corringer
ResearchOpen Access13 Feb 2023
Nature Communications

Volume: 14, P: 1-13
Bidirectional ATP-driven transport of cobalamin by the mycobacterial ABC transporter BacA

ABC transporters are generally considered to be unidirectional. Here, the authors develop a fluorescence-based transport assay and show that the mycobacterial ABC transporter BacA instead acts as a bidirectional transporter for cobalamin.

Mark Nijland
Solène N. Lefebvre
Dirk J. Slotboom
ResearchOpen Access23 Mar 2024
Nature Communications

Volume: 15, P: 1-9
Single-molecule visualization of ATP-induced dynamics of the subunit composition of an ECF transporter complex under turnover conditions

The association and dissociation dynamics of the ECF transporter complex for vitamin B12 are visualized by single-molecule FRET, highlighting the original transport mechanism of this group of ABC transporters.

Solène N. Lefebvre
Mark Nijland
Dirk J. Slotboom
ResearchOpen Access13 May 2025
Nature Communications

Volume: 16, P: 1-12
Conformational transitions of the serotonin 5-HT₃ receptor

Cryo-electron microscopy of the serotonin 5-HT3 receptor in complex with various ligands yields four distinct structures, capturing serotonin binding in detail and increasing understanding of the gating mechanism of the receptor.

Lucie Polovinkin
Ghérici Hassaine
Hugues Nury
Research31 Oct 2018
Nature

Volume: 563, P: 275-279

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Several groups of LysM-RLKs are involved in symbiotic signal perception and arbuscular mycorrhiza establishment

Illumination of a progressive allosteric mechanism mediating the glycine receptor activation

Bidirectional ATP-driven transport of cobalamin by the mycobacterial ABC transporter BacA

Single-molecule visualization of ATP-induced dynamics of the subunit composition of an ECF transporter complex under turnover conditions

Conformational transitions of the serotonin 5-HT3 receptor

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Conformational transitions of the serotonin 5-HT₃ receptor