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Showing 1–5 of 5 results
Advanced filters: Author: Somdutta Dhir Clear advanced filters

  • Mutations in LSM11 and RNU7-1, which encode components of the replication-dependent histone pre-mRNA–processing complex, cause an autoinflammatory syndrome due to enhanced interferon signaling mediated by the cGAS–STING pathway, showing an essential role for nuclear histones in suppressing the immunogenicity of self-DNA.

    • Carolina Uggenti
    • Alice Lepelley
    • Yanick J. Crow
    Research
    Nature Genetics
    Volume: 52, P: 1364-1372

  • Dynamic gene expression is crucial for coordinating diverse cellular activities, but challenging to modulate with high spatiotemporal precision. Now, a photoswitchable DNA structure-specific, small-molecule ligand enables reversible, light-controlled regulation of gene expression and cell proliferation in live cells.

    • Xiaoyun Zhang
    • Somdutta Dhir
    • Shankar Balasubramanian
    ResearchOpen Access
    Nature Chemistry
    Volume: 17, P: 875-882

  • Small nucleolar ribonucleoprotein complexes (snoRNP) are fundamental for ribosome biogenesis. Here the authors provide insight into the 5ʹend processing of S. cerevisiae snoRNA and its important role in downstream nuclear events.

    • Pawel Grzechnik
    • Sylwia A. Szczepaniak
    • Nicholas J. Proudfoot
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14