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Showing 1–6 of 6 results
Advanced filters: Author: Songlin Bai Clear advanced filters

  • In this Perspective, members of the Aging Biomarker Consortium outline the X-Age Project, an Aging Biomarker Consortium plan for building standardized aging clocks in China. The authors discuss the project roadmap and its aims of decoding aging heterogeneity, detecting accelerated aging early and evaluating geroprotective interventions.

    • Jiaming Li
    • Mengmeng Jiang
    • Guang-Hui Liu
    Reviews
    Nature Aging
    Volume: 5, P: 1669-1685

  • Tetrodotoxin and congeners are specific voltage-gated sodium channel blockers that exhibit remarkable anesthetic and analgesic effects but total synthesis procedures are often limited by the scale. Here, the authors present a scalable asymmetric syntheses of Tetrodotoxin and 9-epiTetrodotoxin from the abundant chemical feedstock furfuryl alcohol.

    • Peihao Chen
    • Jing Wang
    • Xiangbing Qi
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-9

  • Producing functional soft fibers via existing spinning methods is environmentally and economically costly due to the complexity of spinning equipment, involvement of copious solvents, intensive consumption of energy. Here, the authors report a nonsolvent vapor-induced phase separation spinning approach under ambient conditions, which resembles the native spider silk fibrillation’.

    • Songlin Zhang
    • Mengjuan Zhou
    • Swee Ching Tan
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • In a new study Yingxian Li and her colleagues show that the microRNA miR-214 targets ATF4 in osteoblasts to negatively regulate their activity. Manipulating miR-214 levels experimentally showed that its elevated expression is sufficient to induce bone loss in mice and that its therapeutic inhibition reduces bone loss in two mouse models.

    • Xiaogang Wang
    • Baosheng Guo
    • Yingxian Li
    Research
    Nature Medicine
    Volume: 19, P: 93-100