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Showing 1–6 of 6 results
Advanced filters: Author: Sonia Assil Clear advanced filters

  • Activation of a crucial immune adaptor protein, STING, is tightly regulated by subcellular trafficking, but how it is deactivated remains less well defined. A study now shows that ESCRT-dependent encapsulation of STING-carrying vesicles by lysosomal compartments — through the process of microautophagy — mediates the termination of STING signalling.

    • Sonia Assil
    • Søren R. Paludan
    News & Views
    Nature Cell Biology
    Volume: 25, P: 379-380

  • STING ER exit is the rate-limiting step in STING signaling, but the mechanism that drives this process is not understood. Paludan and colleagues identify CxORF56, called STEEP here, as a positive regulator of STING signaling.

    • Bao-cun Zhang
    • Ramya Nandakumar
    • Søren R. Paludan
    Research
    Nature Immunology
    Volume: 21, P: 868-879

  • The signaling protein SAM68 mediates apoptosis in macrophages downstream of stimulator of interferon genes (STING) activation.

    • Demi van der Horst
    • Naziia Kurmasheva
    • David Olagnier
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-15