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Showing 1–3 of 3 results
Advanced filters: Author: Sonia Karaz Clear advanced filters

  • Sarcopenia is the loss of muscle mass and strength associated with physical disability during ageing. Here, the authors analyse muscle biopsies from 119 patients with sarcopenia and age-matched controls of different ethnic groups and find transcriptional signatures indicating mitochondrial dysfunction, associated with reduced mitochondria numbers and lower NAD+ levels in older individuals with sarcopenia.

    • Eugenia Migliavacca
    • Stacey K. H. Tay
    • Jerome N. Feige
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • The muscle-secreted, exercise-induced peptide hormone apelin decreases with aging and sarcopenia, and its repletion in aged mice with recombinant protein improves muscle mass and function.

    • Claire Vinel
    • Laura Lukjanenko
    • Cedric Dray
    Research
    Nature Medicine
    Volume: 24, P: 1360-1371