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Showing 1–4 of 4 results
Advanced filters: Author: Sopheak Sim Clear advanced filters

  • The contribution of EMT in mammary gland homeostasis and human breast cancer is still unclear. Here, using in vivo lineage tracing and breast cancer PDXs the authors demonstrate that the repopulating capacity in normal mammary epithelial cells and tumorigenic capacity in breast cancer is independent of expression of EMT-associated genes.

    • Shaheen S. Sikandar
    • Angera H. Kuo
    • Michael F. Clarke
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Not all cells in a tumor are alike, but our ability to characterize cancer heterogeneity in detail has been limited. Dalerba et al. use high-throughput single-cell expression analysis to define clinically relevant subpopulations in normal and cancerous colon tissue.

    • Piero Dalerba
    • Tomer Kalisky
    • Stephen R Quake
    Research
    Nature Biotechnology
    Volume: 29, P: 1120-1127

  • A systematic evaluation of various single-cell RNA-seq approaches reports their sensitivity, accuracy and reproducibility and establishes the high performance of a high-throughput microfluidic method.

    • Angela R Wu
    • Norma F Neff
    • Stephen R Quake
    Research
    Nature Methods
    Volume: 11, P: 41-46

  • The transcriptome changes driving the conversion of fibroblasts to neurons at the single-cell level are reported, revealing that early neuronal reprogramming steps are homogenous, driven by the proneural pioneer factor Ascl1; the expression of myogenic genes then has a dampening effect on efficiency, which needs to be counteracted by the neuronal factors Myt1l and Brn2 for more efficient reprogramming.

    • Barbara Treutlein
    • Qian Yi Lee
    • Stephen R. Quake
    Research
    Nature
    Volume: 534, P: 391-395