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Showing 1–7 of 7 results
Advanced filters: Author: Sophie Duraffour Clear advanced filters
  • It is currently unknown how climate and land use changes could affect the endemic area of Lassa virus, a zoonotic pathogen responsible for Lassa fever. Here, the authors show that by 2070, new regions in Africa will likely become ecologically suitable for Lassa virus, drastically increasing the population living in conditions favourable for virus circulation.

    • Raphaëlle Klitting
    • Liana E. Kafetzopoulou
    • Simon Dellicour
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15
  • The viral lineage responsible for the February 2021 outbreak of Ebola virus disease in Guinea is nested within a clade that predominantly consists of genomes sampled during the 2013–2016 epidemic, suggesting that the virus might have re-emerged after a long period of latency within a previously infected individual.

    • Alpha Kabinet Keita
    • Fara R. Koundouno
    • N’. Faly Magassouba
    Research
    Nature
    Volume: 597, P: 539-543
  • A nanopore DNA sequencer is used for real-time genomic surveillance of the Ebola virus epidemic in the field in Guinea; the authors demonstrate that it is possible to pack a genomic surveillance laboratory in a suitcase and transport it to the field for on-site virus sequencing, generating results within 24 hours of sample collection.

    • Joshua Quick
    • Nicholas J. Loman
    • Miles W. Carroll
    Research
    Nature
    Volume: 530, P: 228-232
  • Fatal Ebola virus disease is characterized by a high proportion of CD4+ and CD8+ T cells expressing the inhibitory molecules CTLA-4 and PD-1, correlating with high virus load; individuals who survive the infection exhibit lower expression of these inhibitory molecules and generate Ebola-specific CD8+ T cells, suggesting that dysregulation of the T cell response is a key component of Ebola virus disease pathophysiology.

    • Paula Ruibal
    • Lisa Oestereich
    • César Muñoz-Fontela
    Research
    Nature
    Volume: 533, P: 100-104