Superoxide dismutase 1 aggregation is critically implicated in the development of amyotrophic lateral sclerosis, however, the mechanistic understanding remains elusive. Here, the authors report the biophysical and spectroscopic investigations of the critical steps in oligomer formation, probing the role of metal ions and disulfide bonds, as well as the mode of action of quercetin as an aggregation inhibitor.
- Vijay Raj Tomar
- Shilpa Sharma
- Shashank Deep
