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Showing 1–3 of 3 results
Advanced filters: Author: Soumitra V. Athavale Clear advanced filters
  • As a unit for enzyme activity, the katal is enigmatic but struggles to find widespread acceptance. Soumitra Athavale tells its story.

    • Soumitra V. Athavale
    Comments & Opinion
    Nature Physics
    Volume: 16, P: 704
  • Enzymes catalyse reactions with unparalleled activity and selectivity. Using chemical insights, researchers can now direct these powerful natural catalysts to perform new-to-nature transformations that solve challenging synthetic problems. In this Perspective, we show how chemists and protein engineers have guided nature’s genetically encoded and evolvable machinery to perform new biocatalytic transformations.

    • David C. Miller
    • Soumitra V. Athavale
    • Frances H. Arnold
    Reviews
    Nature Synthesis
    Volume: 1, P: 18-23
  • The discovery of amplifying autocatalysis in a pyridine-3-carbaldehyde system facilitates a mechanistic deconstruction of the Soai reaction. A tetrameric autocatalyst, assembled by a combination of steric effects and nitrogen–zinc coordination, activates the substrate by two-point binding. This is followed by intra-complex isopropyl group transfer that generates the product alkoxide with high homochiral fidelity.

    • Soumitra V. Athavale
    • Adam Simon
    • Scott E. Denmark
    Research
    Nature Chemistry
    Volume: 12, P: 412-423