AGO-PAR-CLIP is widely used for high-throughput miRNA target characterization. Here, the authors show that the previously neglected non-T-to-C clusters denote functional miRNA binding events, and develop microCLIP, a super learning framework that accurately detects miRNA interactions.
- Maria D. Paraskevopoulou
- Dimitra Karagkouni
- Artemis G. Hatzigeorgiou