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Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development

COBRA1 is a BRCA1-binding protein and, as part of the negative elongation factor, regulates RNA polymerase II pausing and transcription elongation. Here, the authors show that tissue-specific deletion of mouse Cobra1 inhibits postnatal mammary gland development and that the mammary defects can be rescued by additional deletion of Brca1in a DNA repair-independent manner.

Sreejith J. Nair
Xiaowen Zhang
Rong Li
ResearchOpen Access04 Mar 2016
Nature Communications

Volume: 7, P: 1-9
Correction: Author Correction: Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis

Xiaowen Zhang
Huai-Chin Chiang
Rong Li
Amendments and CorrectionsOpen Access30 Mar 2018
Nature Communications

Volume: 9, P: 1
Mending cracks atom-by-atom in rutile TiO₂ with electron beam radiolysis

Radiolysis is known for damaging crystals. Here, using STEM, researchers observed radiolysis-driven bond-breakage, atomic movements, & crystal restructuring in rutile TiO2, and proposed a “2-step rolling” model of building blocks. These results open possibilities for constructive use of radiolysis.

Silu Guo
Hwanhui Yun
K. Andre Mkhoyan
ResearchOpen Access26 Sept 2023
Nature Communications

Volume: 14, P: 1-7
Exploring the impact of southern ocean sea ice on the Indian Ocean swells

Meenakshi Sreejith
Remya P. G.
T. M. Balakrishnan Nair
ResearchOpen Access20 Jul 2022
Scientific Reports

Volume: 12, P: 1-9
Engineering metal oxidation using epitaxial strain

A quest to resolve ultra-high vacuum synthesis of high-quality, single-crystalline metal oxide thin films containing hard-to-oxidize metals reveals a hidden role of epitaxial strain on the metal oxidation chemistry and resulting thin-film growth.

Sreejith Nair
Zhifei Yang
Bharat Jalan
Research22 May 2023
Nature Nanotechnology

Volume: 18, P: 1005-1011
Signal-induced enhancer activation requires Ku70 to read topoisomerase1–DNA covalent complexes

Tan et al. found that topoisomerase-independent DNA nicking is required for most, if not all, signal-induced acute enhancer activation programs, nucleating formation of a Ku70–HP1γ–Med26 complex required to facilitate transcriptional activation.

Yuliang Tan
Lu Yao
Michael G. Rosenfeld
ResearchOpen Access06 Feb 2023
Nature Structural & Molecular Biology

Volume: 30, P: 148-158
Enhancer release and retargeting activates disease-susceptibility genes

Disruption of a promoter can release its partner enhancer to activate other promoters in the same contact domain, and this process, named ‘enhancer release and retargeting’, can often lead to gene alterations that cause disease.

Soohwan Oh
Jiaofang Shao
Michael G. Rosenfeld
Research26 May 2021
Nature

Volume: 595, P: 735-740
Phase separation of ligand-activated enhancers licenses cooperative chromosomal enhancer assembly

After acute agonist stimulation, phase-separated complexes form at estrogen-receptor-bound enhancer sites and coalesce into condensates with cooperative enhancer activity. Chronic stimulation causes the condensates to mature into a less dynamic, gel-like state.

Sreejith J. Nair
Lu Yang
Michael G. Rosenfeld
Research04 Mar 2019
Nature Structural & Molecular Biology

Volume: 26, P: 193-203
Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis

The vast majority of BRCA1-driven breast cancers derive from luminal progenitor cells but the mechanisms of this lineage specificity are unclear. Here the authors show that dangerous accumulation of DNA-RNA hybrid structures due to RNA polymerase II pausing, occurs specifically in luminal epithelial cells.

Xiaowen Zhang
Huai-Chin Chiang
Rong Li
ResearchOpen Access26 Jun 2017
Nature Communications

Volume: 8, P: 1-12

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