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Showing 1–2 of 2 results
Advanced filters: Author: Srinath C. Sampath Clear advanced filters

  • Cellular fusion is essential for skeletal muscle development. Here the authors identify Minion as a microprotein required for myoblast fusion and skeletal muscle formation, and show that co-expression of Minion and Myomaker is sufficient to induce cytoskeletal rearrangement and cell fusion even in non-muscle cells.

    • Qiao Zhang
    • Ajay A. Vashisht
    • Srihari C. Sampath
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • The factors that mediate quiescence of muscle stem cells are unknown. The authors show that Oncostatin M is produced by skeletal muscle, suppresses stem cell proliferation, and that its deletion in muscle results in stem cell depletion and impaired muscle regeneration following injury in mice.

    • Srinath C. Sampath
    • Srihari C. Sampath
    • Helen M. Blau
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9