Deep learning enhanced chemical imaging delineated polymorphic Aβ plaques in situ. Cored plaques were associated with increased Aβ1-40 and 3pE-42 deposition. A distinct, coarse-grained plaque phenotype was specific to AD, showed increased neuritic dystrophy and an Aβ-pattern similar to CAA.
- Srinivas Koutarapu
- Junyue Ge
- Jörg Hanrieder
