Nature Search

Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy

Genome-wide association analyses comprising 14,256 cases and 1,199,156 controls and incorporating correlated cardiac magnetic resonance imaging traits provide insights into the molecular etiology of dilated cardiomyopathy.

Sean L. Zheng
Albert Henry
R. Thomas Lumbers
ResearchOpen Access21 Nov 2024
Nature Genetics

Volume: 56, P: 2646-2658
Stimuli-sensitive intrinsically disordered protein brushes

Polymer brush surface coatings are important biomaterials for the reduction of biomolecule and cell adhesion. Here, the authors use a recombinantly expressed, intrinsically disordered protein to form a stimuli-responsive and enzyme-active polymer brush surface.

Nithya Srinivasan
Maniraj Bhagawati
Sanjay Kumar
Research14 Oct 2014
Nature Communications

Volume: 5, P: 1-8
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Protein-altering germline mutations implicate novel genes related to lung cancer development

In lung cancer, relatively few germline mutations are known to impact risk. Here the authors looked at rare variants in 39,146 individuals and find novel germline mutations associated with risk, as well as implicating ATM and a new candidate gene for lung cancer risk.

Xuemei Ji
Semanti Mukherjee
Christopher I. Amos
ResearchOpen Access11 May 2020
Nature Communications

Volume: 11, P: 1-14
Achieving single nucleotide sensitivity in direct hybridization genome imaging

Visualisation of point mutations in situ is informative for studying genetic diseases. Here the authors report single guide genome oligopaint via local denaturation fluorescence in situ hybridisation, sgGOLDFISH, a direct hybridisation genome imaging method with single-nucleotide sensitivity.

Yanbo Wang
W. Taylor Cottle
Taekjip Ha
ResearchOpen Access15 Dec 2022
Nature Communications

Volume: 13, P: 1-12
Outcomes of COVID-19 and risk factors in patients with cancer

Pramesh and colleagues report a study on the risk factors and outcomes in a large cohort of patients with cancer infected with SARS-CoV-2 from a tertiary care cancer center in India.

Manju Sengar
Girish Chinnaswamy
Virendra Tiwari
Research04 Apr 2022
Nature Cancer

Volume: 3, P: 547-551
A deep learning framework identifies dimensional representations of Alzheimer’s Disease from brain structure

Alzheimer’s disease is heterogeneous in its neuroimaging and clinical phenotypes. Here the authors present a semi-supervised deep learning method, Smile-GAN, to show four neurodegenerative patterns and two progression pathways providing prognostic and clinical information.

Zhijian Yang
Ilya M. Nasrallah
Balebail Ashok Raj
ResearchOpen Access03 Dec 2021
Nature Communications

Volume: 12, P: 1-15
Malaria vaccine candidate based on Duffy-binding protein elicits strain transcending functional antibodies in a Phase I trial

Kavita Singh
Paushali Mukherjee
Chetan E. Chitnis
ResearchOpen Access28 Sept 2018
npj Vaccines

Volume: 3, P: 1-10
Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders

Sven Ruf
Sridharan Rajagopal
Aimo Kannt
ResearchOpen Access14 Sept 2022
Scientific Reports

Volume: 12, P: 1-18
Optical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis

Srinivasan Sanjay
Santosh Gopi Krishna Gadde
Rohit Shetty
ResearchOpen Access03 Sept 2021
Scientific Reports

Volume: 11, P: 1-12
Development and validation of a simplified thoracolumbar spine fracture classification system

Harvinder Singh Chhabra
P K Karthik Yelamarthy
Md Fazlul Hoque
Research27 Sept 2021
Spinal Cord

Volume: 59, P: 1268-1277
Characterization of protein extracts from different types of human teeth and insight in biomineralization

Vaibhav Sharma
Alagiri Srinivasan
Saroj Kumar
ResearchOpen Access27 Jun 2019
Scientific Reports

Volume: 9, P: 1-9
A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders

Aimo Kannt
Sridharan Rajagopal
Saravanakumar Dhakshinamoorthy
ResearchOpen Access26 Feb 2018
Scientific Reports

Volume: 8, P: 1-15
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952

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